A Journey with Elie Metchnikoff: From Innate Cell Mechanisms in Infectious Diseases to Quantum Biology
نویسنده
چکیده
Many reviews of Elie Metchnikoff's work have been published, all unanimously acknowledging the significant contributions of his cellular theory to the fields of immunology and infectious diseases. In 1883, he published a key paper describing phagocytic cells in frogs. His descriptions were not just about phagocytes involved in host defense, he also described how these specialized cells eliminated degenerating or dying cells of the host. This perspective focuses on key concepts developed by Metchnikoff by presenting relevant excerpts of his 1883 paper and matching these concepts with challenges of modern immunology. A new approach to macrophage polarization is included to introduce some creative thinking about the exciting emerging area of quantum biology.
منابع مشابه
Phagocytosis: The Legacy of Metchnikoff
This year is the centenary of the death of Elie Metchnikoff, the father of innate immunity. His work on phagocytosis has continued to flourish, particularly over the past half century.
متن کاملElie Metchnikoff: father of natural immunity.
We celebrate the centenary of the Nobel award to Elie Metchnikoff in 2008, shared with Paul Ehrlich, as respective pioneers of cellular and humoral immunology. Metchnikoff is rightly famous for his recognition of the biological significance of leukocyte recruitment and phagocytosis of microbes in host defence against infection, inflammation and immunity. As a comparative zoologist he utilised a...
متن کاملProgrammed cell death and apoptosis--where it came from and where it is going: from Elie Metchnikoff to the control of caspases.
The story of cell death began with the origins of cell biology, including important observations by Elie (Ilya) Metchnikoff, who realized that phagocytes engulfed dying cells. Most of the early studies were observational. By the middle of the 20th C, researchers were beginning to explore how cells died, had recognized that cell death was a physiologically controlled process, that the most commo...
متن کاملThe Origin of a Paradigm.
In this issue of the Journal of Innate Immunity , we are privileged to publish an article by Siamon Gordon [1] , Professor Emeritus of Cellular Pathology at the University of Oxford, commemorating the life and achievements of Elie Metchnikoff (1845–1916). Siamon Gordon is an outstanding scientist in the field of macrophage research and has made many important discoveries, e.g. the pattern recog...
متن کاملThe Romantic Rationalist: a Study of Elie Metchnikoff.
TOWARDS the end of his life the tall, gaunt, stooping figure of Elie Metchnikoff (the French form of his name which he used for the last twenty-five years of his life) with long unkempt hair and flowing beard was almost a caricature of the Russian Bolshevik emigre'. He might have stepped from the pages ofa Dostoyevsky novel. His personality too seems to have combined the Rational and Romantic e...
متن کامل